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. 2016 Feb 26;7(13):17162–17181. doi: 10.18632/oncotarget.7751

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Copyright: © 2016 Fu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. A significant increase in cell apoptosis/death was observed in SCC4 cells on treatment with ER maleate (2μM), or CBP (25μM) alone, or their combination for 24h, 48h and 72h, respectively. CBP treatment induced apoptotic cell population and this induction was further enhanced by combining with ER maleate. B. Histogram showed the change in apoptotic cell percentage of SCC4 cells on treatment with ER maleate (2μM), or CBP (25μM) alone or their combination. C. An increase in apoptosis was also observed in Cal33 cells on treatment with ER maleate, or CBP (25μM) alone or their combination for 24h, 48h and 72h, respectively. CBP treatment induced apoptotic cell population and this induction was further enhanced by combining with ER maleate. D. Histogram showed the change in apoptotic cell percentage of Cal33 cells on treatment with ER maleate (2μM), or CBP (25μM) alone or their combination. The bar graph data were presented as mean ± SEM; groups denoted by different letters represent a significant difference at p < 0.05 (ANOVA followed by Fisher's LSD test).