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Structural basis for EVN/AVI resistance via methylation of the 23S rRNA residues. (A) The 2′O-methylation of U2479 in H89 by AviRb (14) clashes with the ring F of the drug. (B) N7 methylation of G2535 in H91 by AviRa (14) is located distal from the AVI binding site. (C) Methylation of the 2′OH of the ribose or N2 position in the nucleobase of G2470 by EmtA (13) clashes with EVN (gold), whereas the N7 position is distal to the drug-binding site.
