Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
EVN and AVI specifically block accommodation of A-tRNA into the classical state. Representative smFRET traces exemplifying the processes shown in Fig. 5 C–E are shown. (A) In the absence of drug, aa-tRNA rapidly achieves the fully accommodated A/A state (0.63 FRET) via reversible forward-sampling from the 0.35 FRET A/T state. (B and C) AVI (B) and EVN (C) inhibit formation of the A/A state, leading to repeated, unsuccessful sampling events.
