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. 2016 Jun 20;113(27):E3824–E3833. doi: 10.1073/pnas.1600633113

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Fig. 7. — Scheme of chimeric kinases designed to test contributions of the autoregulatory and CaM-binding sequences to the Ca²⁺/CaM-independent activity of cMLCK. Names of chimeras correspond to sequence origin for interchanged segments. Ca-Ca-Sk is truncated cMLCK with skMLCK CaM binding sequence; Ca-Sk-Sk is truncated cMLCK with skMLCK autoinhibitory and CaM binding sequence; Ca-Ca-Ca is WT cMLCK; Sk-Sk-Ca is truncated skMLCK with cMLCK CaM binding sequence; Sk-Ca-Ca is truncated skMLCK with cMLCK autoinhibitory and CaM binding sequence; and Sk-Sk-Sk is WT skMLCK.