Fig. S4.

Down-regulation of Fmr1 expression in the mushroom body leads to diminished forgetting. UAS-Fmr1-RNAi³⁴⁹⁴⁴ flies were crossed with WT flies (+) and the MB Gal4, OK107. (A) No effect on learning was found when Fmr1 was down-regulated in the mushroom body. (B) Reversal-learning was reduced in UAS-Fmr1-RNAi³⁴⁹⁴⁴/+;OK107/+ flies with down-regulation of FMRP in the mushroom body. (C) Down-regulation of FMRP expression led to enhanced old memory in transgenic flies subjected to reversal-learning training.