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SAG treatment of Shhcre;Rfwd2 mutant lungs led to attenuation of the tip dilation phenotype. (A) qRT-PCR analysis of genes Shh, Fgf10, and Foxa2 in Shhcre;Rfwd2 mutants compared with control at E13.5. n = 3 in each group. *P < 0.05; **P < 0.01. Representative images of E11.5 lungs cultured for 48 h in either DMSO (B, C, F, and G) or SAG (50 nM) (D, E, H, and I) are shown. Red lines outline the branch tips. (Scale bars: 500 μm.)
