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Cartoon of intracellular movements during gating. A summary is provided of measured distances between the I6 (yellow) and I10 (blue) fluorophores in the resting (Left), active (Middle), and desensitized (Right) receptor states relative to the cell membrane (axial) and the channel center axis (radial). Note that the FRET distance can remain similar even if the fluorophores approach laterally, due to changes in axial separation.
