Table S2.
l-glutamate | CTZ | DNQX | |
Receptor | EC50,† μM | EC50,† μM | IC50,† nM |
WT GluA2 | 28 [27–31] | 6 [5–9] | 1154 [857–1552] |
GluA2-0Y-6C | 81 [66–100] | 11 [8–15] | 562 [391–809] |
GluA2-0Y-10C | 30 [27–33] | 9 [6–13] | 845 [308–2598] |
GluA2-3Y-6C | 108 [99–117]* | 7 [5–10] | 156 [90–271]* |
GluA2-3Y-10C | 25 [22–29] | 9 [7–11] | 444 [234–843] |
GluA2-6Y-10C | 46 [41–50] | 12 [10–15] | 163 [50–535]* |
P < 0.05 value statistically significantly different from WT GluA2.
Data represent EC50 or IC50 obtained from fitting of composite dose–response data (Fig. S1) from experiments at five to nine oocytes (95% confidence intervals in brackets).