Table S1.

Association of extensive disease at follow-up, FVC% decline >5% and FVC <70% at follow-up, circulating Ox40L, and clinical parameters in the Oslo University Hospital SSc cohort (n = 241) in multivariable logistic regression

	FVC <70% at follow-up (range)	P value	Annual FVC decline >5% (range)	P value	Extensive lung disease* (range)	P value
OX40l	1.3 (1.01–1.80)	0.047	1.4 (1.06–1.79)	0.017	1.5 (1.03–2.31)	0.037
Anti-centromere Ab	NS	NS	NS	NS	NS
dcSSc	4.1 (1.22–13.81)	0.027	NS	NS	NS
Fibrosis at baseline	1.2 (1.09–1.22)	<0.001	NS	NS	1.3 (1.14–1.45)	<0.001
Age at disease onset	NS	NS	1.04 (1.01–1.07)	0.019	NS	NS

All values are adjusted for gender. Ab, antibody; dcSSc: diffuse cutaneous systemic sclerosis; FVC, forced vital capacity; NS, not significant.

*Defined by Goh and Wells (44) as >20% extent of interstitial lung disease (ILD) on HRCT and 10–30% extent of ILD and FVC <70%.