Table 3.

Gene set enrichment analysis

Top gene set enrichment analysis signaling pathways	Enrichment score	P value
PDGF receptor → AP-1/MYC	−0.51	<1 × 10−5
HGFR → AP-1/CREB/MYC	−0.50	<1 × 10−5
TGFBR → AP-1	−0.49	<1 × 10−5
Angiopoietin → AP-1	−0.47	<1 × 10−5
Notch → NFκB	−0.45	<1 × 10−5
IL1R → NFκB	−0.44	<1 × 10−5

A transcriptomic approach was performed to compare genes differentially expressed between ox40l^+/+ (n = 3) and ox40l^−/− mice (n = 4) injected with bleomycin. Gene Set Enrichment Analysis showed an up-regulation of genes involved in two main pathways: the NFκB and AP1 pathways. CREB: cAMP response element binding protein; HGFR: hepatocyte growth factor receptor; PDGFR, PDGF receptor; TGFBR: TGF-β receptor.