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. 2016 Jul 11;6:29431. doi: 10.1038/srep29431

Figure 4. The charged residues of the Kv1.3 channel are involved in the recognition of sBmP02.

Figure 4

(A,B) Current responses of mutant channels H451V and D433A, respectively, test voltage of +40 mV in the presence of vehicle control (in black trace) or in presence of 100 nM sBmP02. (C,D) Representative currents of mutant channels D421A and D422A in the absent (black) and present of 300 nM sBmP02. (E) The fraction current of WT Kv1.3 and mutant H451V, D421A and D422A at the presence of 300 nM sBmP02. (F) The dose-response relationship of sBmP02 inhibiting mutant channels H451V, D433A, D421A and D422, respectively.