Skip to main content
. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Eur J Pharmacol. 2015 Jun 20;764:30–37. doi: 10.1016/j.ejphar.2015.06.041

Fig. 2.

Fig. 2

A. Amitifadine effects on locomotor activity in the figure-8 maze averaged over the one-hour test session (mean±S.E.M.). Dunnett’s comparisons showed that the 30 mg/kg dose of amitifadine significantly (*P<0.005) reduced locomotor activity but the lower doses did not. N=10.

B. Amitifadine effects on locomotor activity in the figure-8 maze during each five-min block of the one-hour test session (mean±S.E.M.). There was a significant main effect of block (F(11,297)=28.22, P<0.0005). There was also a significant interaction of amitifadine × time block (F(33,297)=1.84, P<0.005). Tests of the simple main effects comparing each dose to control at each block showed that 30 mg/kg decreased activity at blocks 1 (P<0.0005), 2 (P<0.0005), 3 (P<0.005) and 7 (P<0.05). The 10 mg/kg dose decreased activity at block 1 (P<0.005) and block 2 (P<0.05) and increased activity at block 4 (P<0.05). The 5 mg/kg dose increased activity at block 4 (P<0.05) and block 6 (P<0.05). N=10.