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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Eur J Pharmacol. 2015 Jun 20;764:30–37. doi: 10.1016/j.ejphar.2015.06.041

Fig. 4.

Fig. 4

Fig. 4

A. Chronic amitifadine effects on nicotine self-administration over weeks. Chronic amitifadine had a significant (P<0.0005) main effect reducing nicotine self-administration (mean±S.E.M.). There was no apparent diminution of effect from the first week of dosing to the second or to the week of resumed after a 9-day period of enforced abstinence. Control N=10, Amitifadine N=12.

B. Chronic amitifadine effects on nicotine self-administration over 15 min blocks. In the chronic study, amitifadine had continued efficacy over the three 15-min. blocks during the test session (mean±S.E.M.) averaged over all sessions Amitifadine main effect (P<0.0005). Control N=10, Amitifadine N=12.

C. Chronic amitifadine effects on nicotine self-administration, session-by-session results. Amitifadine had continued efficacy (mean±S.E.M.) over the 10 sessions of chronic treatment and 5 session of resumed access after enforced abstinence, aamitifadine main effect (P<0.0005). Control N=10, Amitifadine N=12.