Table 3.
Post‐vaccination and post‐challenge survival, weight dynamics, and levels of challenge virus in the lung of mice
| Vaccine | Dose | Post‐vaccination | Post‐challenge | ||||
|---|---|---|---|---|---|---|---|
| Survival* | Weight** | Virus in lung*** | Survival | Weight | |||
| Inactivated | μg HA | % | % | Log TCID50 | % | % | |
| Whole | H5N1 | 2·5 | 97 | 102 ± 3 | 1 ± 1 | 95 | 95 ± 8 |
| Whole | H5N1 | 0·5 | 100 | 105 ± 4 | 2 ± 1 | 80 | 83 ± 11 |
| Split | H5N1 | 2·5 | 99 | 105 ± 5 | 4 ± 0·5 | 70 | 79 ± 14 |
| Split | H5N1 | 0·5 | 99 | 105 ± 4 | 5·5 ± 1 | 17 | 74 ± 16 |
| Whole | H1N1 | 2·5 | 100 | 101 ± 5 | 5·5 ± 1 | 0 | 72 ± 8 |
| Live | TCID 50 | ||||||
| VN‐PR8 | H5N1 | 106 | 20 | 78 ± 6 | 1 ± 1 | 98 | 94 ± 6 |
| Ku‐at | H5N1 | 106 | 79 | 84 ± 5 | 1 ± 0·8 | 98 | 92 ± 6 |
| VN‐Len | H5N2 | 106 | 97 | 93 ± 4 | 2 ± 1 | 94 | 88 ± 7 |
| VN‐Gull | H5N2 | 106 | 92 | 88 ± 7 | 1·5 ± 1 | 97 | 93 ± 5 |
| Ku‐Len | H5N2 | 106 | 97 | 96 ± 5 | 2 ± 1·3 | 95 | 90 ± 9 |
| Ku‐Gull | H5N2 | 106 | 90 | 89 ± 10 | 1·5 ± 1·3 | 97 | 91 ± 6 |
| NC‐Len | H1N1 | 106 | 97 | 95 ± 6 | 4·7 ± 0·8 | 90 | 77 ± 5 |
| Placebo | – | 99 | 105 ± 3 | 6 ± 0·7 | 0 | 70 ± 4 | |
Mice were exposed to single vaccination in indicated dose and challenged by H5N1 A/Chicken/Kurgan/3/05 virus (∼100 LD50) on day 30 post‐vaccination.
*Survival: Percentage survival of three experiments;
**Weight: Average mouse weight, percentage of start value (average for three experiments) determined on day 6 post‐vaccination or post‐challenge.
***Challenge virus in the lung, log10 of TCID50 value, average for nine mice of three experiments.