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Titers of hemagglutinin‐specific IgG antibodies in mice immunized with HAC1. Mice were immunized with HAC1 twice, at days 0 and 21, and serum samples were collected prior to each immunization, as well as 10 and 21 days after the second dose (study days 31 and 42, respectively). The HAC1 antigen was administered to mice either in the presence of Quil A (s.c.) or adsorbed to Alhydrogel (i.m.). Anti‐A/California/07/09 IgG antibody titers were expressed as the mean serum IgG titers ± SE.
