Table 1.
Serum HI antibody responses against homologous virus elicited by seasonal influenza hemagglutinin antigens in mice
| GMT* | Seropositive rate (%)** | ||||
|---|---|---|---|---|---|
| Pre‐immune | Post‐primary | Post‐first boost | Post‐second boost | ||
| PBS/Quil A | 10 ± 0 | 10 ± 0 | 10 ± 0 | 10 ± 0 | 0/0 |
| HAB1(H1) | |||||
| 60 μg | 10 ± 0 | 10 ± 0 | 20·0 ± 24·5 | 71·3 ± 98·8 | 33·3/83·3 |
| 30 μg | 10 ± 0 | 10 ± 0 | 15·9 ± 11·5 | 100·8 ± 56·0 | 16·7/100 |
| 15 μg | 10 ± 0 | 10 ± 0 | 22·4 ± 24·1 | 113·1 ± 21·7 | 33·3/100 |
| PBS/Quil A | 10 ± 0 | 10 ± 0 | 10 ± 0 | 10 ± 0 | 0/0 |
| HAB1(H3) | |||||
| 60 μg | 10 ± 0 | 10 ± 0 | 25·2 ± 5·4 | 80·0 ± 45·1 | 50/83·3 |
| 30 μg | 10 ± 0 | 10 ± 0 | 56·6 ± 20·6 | 359·2 ± 96·3 | 83·3/100 |
| 15 μg | 10 ± 0 | 10 ± 0 | 50·4 ± 27·6 | 63·5 ± 25·5 | 66·7/83·3 |
| PBS/Quil A | 10 ± 0 | 10 ± 0 | 10 ± 0 | 10 ± 0 | 0/0 |
| HAF1(B) | |||||
| 60 μg | 10 ± 0 | 10 ± 0 | 25·2 ± 25·0 | 142·5 ± 133·7 | 33·3/83·3 |
| 30 μg | 10 ± 0 | 10 ± 0 | 28·3 ± 13·4 | 142·5 ± 89·1 | 50/100 |
| 15 μg | 10 ± 0 | 10 ± 0 | 14·1 ± 11·7 | 100·8 ± 42·7 | 16·7/83·3 |
HI, hemagglutination inhibition; PBS, phosphate‐buffered saline.
*GMT, geometric mean titer of HI antibodies ± SE.
**Post‐first boost/post‐second boost.