Table 3.
Clinical course, treatment, and complications
| Overall (n = 100) | Wave 1 (n = 19) | Wave 2 (n = 81) | P | |
|---|---|---|---|---|
| Clinical course and management | ||||
| Days of symptoms, median (IQR) | 12·5 (6–18) | 18 (7–19·25) | 10 (6–16·75) | 0·149 |
| Days of fever, median (IQR) | 2 (1–4) | 2 (1–3) | 2 (1–4) | 0·443 |
| Days of viral shedding, median (IQR) | 46 (14–85) | 98·5 (28·25–157·25) | 38 (13–70) | 0·034 |
| Antiviral therapy | 89 (89·0) | 12 (63·2) | 77 (95·1) | 0·001 |
| Early antiviral therapy | ||||
| Within 24 hours of symptom onset | 36/85 (42·4) | 2/11 (18·2) | 34/74 (45·9) | 0·108 |
| Within 48 hours of symptom onset | 49/85 (57·6) | 6/11 (54·5) | 43/74 (58·1) | 1·000 |
| Antiviral duration | ||||
| Standard (5 days) | 70/87 (80·5) | 8/11 (72·7) | 62/76 (81·6) | 0·443 |
| Extended (>5 days) | 17/87 (19·5) | 3/11 (27·3) | 14/76 (18·4) | |
| Antibiotic treatment | 56 (56·0) | 9 (47·4) | 47 (58·0) | 0·400 |
| Oxygen supplementation | 4 (4·0) | 2 (10·5) | 2 (2·5) | 0·162 |
| Respiratory complications* | 9 (9·0) | 1 (5·3) | 8 (9·9) | 1·000 |
| Upper respiratory tract | 7 (7·0) | 1 | 6 | |
| Asthma exacerbation | 2 (2·0) | 0 | 2 | |
| Extra‐respiratory complications | 39 (39·0) | 8 (42·1) | 31 (38·3) | 0·758 |
| Hematologic | 50 (50·0) | 13 | 37 | |
| Non‐hematologic | 11 (11·0) | 5 | 6 | |
| Laboratory‐confirmed infections | 5 (5·0) | 1 (5·3) | 4 (4·9) | 1·000 |
| Bacterial | 2 (2·0) | 0 | 2 | |
| Fungal | 1 (1·0) | 1 | 0 | |
| Viral | 2 (2·0) | 0 | 2 | |
| Alteration of chemotherapy** | 43/82 (52·42) | 9/17 (52·9) | 34/65 (52·3) | 0·963 |
| Severe outcomes | ||||
| Hospitalization | 51/99 (51·5) | 10 (52·6) | 41/80 (51·2) | 0·914 |
| Duration, d, median (IQR) | 5 (3–13) | 8 (4–68·5) | 5 (3–10·75) | 0·143 |
| Pneumonia*** | 10 (10·0) | 2 (10·5) | 8 (9·9) | 1·000 |
| ICU admission† | 1 (1·0) | 0 (0·0) | 1 (1·2) | 1·000 |
| Need for mechanical ventilation | 0 (0·0) | – | – | – |
| Death | 0 (0·0) | – | – | – |
Data are n (%) unless otherwise indicated. Bold values in tables indicate P‐values lower than the significance level α = 0.05.
*Excludes radiologically confirmed pneumonia.
**Denominators exclude patients not scheduled for chemotherapy.
***Radiologically confirmed.
†None required ventilation, inotropes, dialysis, or extracorporeal membrane oxygenation.