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. 2016 Jul 12;6:29559. doi: 10.1038/srep29559

Figure 6. Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the intracellular accumulation of imatinib and nilotinib.

Figure 6

Intracellular accumulation after 120 min of incubation (N = 3) at different concentrations of (a) 14C-imatinib or (b) 14C-nilotinib in HEKpcDNA3.1, HEK1236C>T-2677G>T-3435C>T. The intracellular accumulation of imatinib or nilotinib in each cell line was normalized by reporting the absolute radioactivity on the total amount of proteins in cell extracts (DPM per mg of protein).