Table 3. Summary of multifactor dimensionality reduction (MDR) models for gene-gene interactions in breast cancer.

No. of factors	Best candidate model	Test balance accuracy	Cross-validation consistency	P-value
One factor	MTHFR rs1801131	0.4822	7/10	0.32
Two factors	MTRR rs162036	0.4974	5/10	0.02
	MTR rs1805087
Three factors	MTHFR rs1801131	0.4926	5/10	<0.01
	MTHFR rs1801133
	MTR rs1805087
Four factorsa	MTRR rs162036	0.5371	10/10	<0.01
	MTR rs1805087
	MTHFR rs1801131
	MTHFR rs1801133
Five factors	MTRR rs162036	0.5301	10/10	<0.01
	MTR rs1805087
	MTHFR rs1801131
	MTHFR rs1801133
	MTRR rs1801394

^aBest model predicted for breast cancer risk with highest cross-validation consistency and maximum test balance accuracy.