Table 5. Associations between gene-nutrition interactions and breast cancer risk by logistic regression analysis.
| Gene | Genotypes | Folate intake below median (<214.7 μg/d) |
Folate intake above median (≥214.7 μg/d) |
Ptrendb | Pinteraction | Bonferroni Pinteraction | ||
|---|---|---|---|---|---|---|---|---|
| Case/Control | Adjusted OR (95% CI)a | Case/Control | Adjusted OR (95% CI)a | |||||
| MTHFR rs1801131 | 0.46 | 1.00 | ||||||
| TT (wild-type) | 232/171 | 1.00 (reference) | 98/179 | 0.44 (0.31-0.62) | <0.01 | |||
| GA + AA | 161/117 | 1.07 (0.78–1.48) | 79/109 | 0.58 (0.40–0.84) | <0.01 | |||
| Ptrendc | 0.66 | 0.18 | ||||||
| MTHFR rs1801133 | 0.01 | 0.05 | ||||||
| GG (wild-type) | 217/174 | 1.00 (reference) | 103/142 | 0.66 (0.47–0.92) | 0.04 | |||
| GA + AA | 176/114 | 1.28 (0.93–1.77) | 74/146 | 0.42 (0.29–0.61) | <0.01 | |||
| Ptrendc | 0.17 | 0.02 | ||||||
| MTRR rs162036 | 0.29 | 1.00 | ||||||
| AA (wild-type) | 249/179 | 1.00 (reference) | 111/192 | 0.44 (0.32–0.60) | <0.01 | |||
| GA + GG | 144/109 | 0.98 (0.71–1.36) | 66/96 | 0.57 (0.38–0.84) | 0.01 | |||
| Ptrendc | 0.98 | 0.14 | ||||||
| MTRR rs1801394 | 0.96 | 1.00 | ||||||
| AA (wild-type) | 211/157 | 1.00 (reference) | 102/157 | 0.48 (0.34–0.68) | <0.01 | |||
| GA + GG | 182/131 | 0.96 (0.70–1.31) | 75/131 | 0.46 (0.32–0.66) | <0.01 | |||
| Ptrendc | 0.76 | 0.95 | ||||||
| MTR rs1805087 | 0.11 | 0.55 | ||||||
| AA (wild-type) | 305/231 | 1.00 (reference) | 148/223 | 0.53 (0.40–0.71) | <0.01 | |||
| GA + GG | 88/57 | 1.17 (0.79–1.73) | 29/65 | 0.37 (0.23–0.61) | <0.01 | |||
| Ptrendc | 0.46 | 0.17 | ||||||
CI, confidence interval; OR, odds ratio.
aOdds ratio adjusted for age, marital status, SES, family history of cancer, history of benign breast disease, live births, months of breast-feeding, passive smoking from husband, alcohol drinking, physical activity, menopausal status, BMI, nulliparous and oral contraceptive use.
bTest for linear trend was calculated based on the estimates for folate intake category (coded 1, 2).
cTest for linear trend was calculated based on the estimates for SNP genotypes category (coded 1, 2).