Table 2. Univariate and multivariate Cox regression analysis for overall survival of gastric cancer patients.

Variables	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Gender
Male vs female	1.292	0.791–2.110	0.313
Age (years)
≥60 vs <60	1.373	0.859–2.195	0.237
Tumor site
Cardia+body vs antrum	1.263	0.777–2.053	0.318
Lauren type
Diffuse+mixture vs intestinal	1.494	0.920–2.426	0.123
Differentiation
Poorly vs well/moderately	1.140	0.638–2.039	0.708
Vessel invasion
Positive vs negative	2.711	1.588–4.628	<0.001	1.543	0.939–2.534	0.087
T stage
T3–T4 vs T1–T2	3.516	2.104–5.877	<0.001	4.863	1.192–19.847	0.027
Lymph node metastasis
Positive vs negative	4.038	2.516–6.481	<0.001	3.425	1.108–10.589	0.033
Distant metastasis
M1 vs M0	19.81	1.234–318.1	0.046	1.334	0.314–5.662	0.696
TNM stage
III–IV vs I–II	4.258	2.656–6.825	<0.001	0.867	0.239–3.142	0.828
calpain-9 expression
High vs low	0.280	0.175–0.450	<0.001	0.387	0.209–0.715	0.002

CI, Confidence interval; HR, Hazard ratio; P < 0.05 was considered to be statistically significant.