FIGURE 1.

Preservation statistic of modules detected in the test sub-dataset in the reference sub-dataset. The Z_summary = 2 and Z_summary = 10 thresholds are indicated by dashed lines. Z_summary less than 2 implies no evidence of module preservation, which indicates strong evidence of module specificity. Z_summary between 2 and 10 implies modest evidence of module preservation and Z_summary more than 10 implies strong evidence of module preservation, which indicates modest or no evidence of module specificity. (A) Module preservation of AD APOE ε4 carriers in AD APOE ε4 non-carriers; (B) Module preservation of AD APOE ε4 carriers in control APOE ε4 carriers; (C) Module preservation of AD APOE ε4 non-carriers in AD APOE ε4 carriers; (D) module preservation of AD APOE ε4 non-carriers in control APOE ε4 non-carriers. See Supplementary Table S2 for exact Z_summary statistics.