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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: IEEE J Sel Top Quantum Electron. 2016 Apr 12;22(4):6803913. doi: 10.1109/JSTQE.2016.2553084

Table 1.

Overview of Magnetic and Plasmonic OCT Experiments

Citation Type of particle# Particle
coating		 Size (nm)## Con-
centration### 		Type of sample Application
Magnetic Nanoparticles OCT Oh, 2008 [64] Inline graphic MIO, bead Dextran 5 (core), 40 (OD) 0.2 mM Fe/kg ex vivo rabbit tissue atherosclerosis
Oldenburg, 2010 [74] Inline graphic Feridex™, cluster Dextran 5 (core)**, 36-100 (OD) 70 μg/mL ex vivo porcine artery thrombosis
Oldenburg, 2012 [75] Inline graphic MIO, bead Dextran 10-20 (core), 20-30 (OD) 41-43 μg/mL ex vivo blood clots thrombosis
Oh, 2007 [63] Inline graphic Feridex™, cluster Dextran 5 (core)**, 36-100 (OD) 1.5 mM Fe/kg ex vivo liver, spleen macrophages
Oldenburg, 2005 [4] Inline graphic Fe3O4, bead (none) 20-30 (core) NA in vivo tadpole optical biopsy
John, 2010 [79] Inline graphic MIO, bead Antibody,
dextran		 20-30 (core) NA in vivo rat tumor breast cancer
Oldenburg, 2008 [81] Inline graphic Fe3O4, bead (none) 20-30 (core) 2 nM* phantom tumor imaging
Inline graphic MIO, sphere COOH 20 (core), 22 (OD) NA ex vivo rat tumor
John, 2012 [82] Inline graphic Ferrofluid/dye-filled
protein sphere		 Peptide 20-30 (core)**,
2000-5000 (OD)		 1 × 1011/mL ex vivo rat tumor cancer
Kim, 2013 [30] Inline graphic Ferrofluid/dye-filled
protein sphere		 Peptide 20-30 (core)**,
2000-5000 (OD)		 .001pM liquid phantom intravascular
Wang, 2010 [88] Inline graphic MIO, bead Streptavidin 1000 (core) <4 mg/mL in vivo mouse eye anterior eye
in vitro mouse eye
Kim, 2014 [83] Inline graphic Ferrofluid/dye-filled
protein sphere		 Peptide 20-30 (core)**,
2000-5000 (OD)		 4.48 pM ex vivo porcine artery atherosclerosis
Huang, 2015 [25] Inline graphic Fe3O4, cluster NA NA <150 ppm cell culture cancer
Oldenburg, 2005 [60] Inline graphic Fe3O4, powder (none) 1920 (core) <1.2 mg/mL cell culture cell labeling
OCE Crecea, 2009 Inline graphic Fe3O4, bead (none) 25 (core) 2.5 mg/mL phantom rheology
Crecea, 2013 [70] Inline graphic Fe3O4, bead (none) 25 (core) NA ex vivo rabbit tissue microrheology
Ahmad, 2014 [29] Inline graphic Fe3O4, bead (none) 50-100 (core) 250 mg/mL phantom elastography
<250 mg/mL ex vivo rat liver
<250 mg/mL ex vivo chicken muscle
OCM Crecea, 2014 [71] Inline graphic Ferrofluid-filled
protein sphere		 NA 900-3500 (OD) NA 3D mammary cell culture cellular mechanics
Inline graphic MIO, bead PS & dye 1000-2000 (OD)
ODT Kim, 2007 Inline graphic Feridex™ Dextran 5 (core)**, 36-100 (OD) 360 μg Fe / mL* capillary tube fluid flow
Plasmonic Nanoparticles DOCT Lee, 2011 Inline graphic Gold, ring PEG 179 (OD), 149 (ID), 97(h) <40 pM ex vivo mouse liver drug delivery
Chhetri, 2011[57] Inline graphic Gold, rod CTAB 53 (L), 15 (d) 1320 pM viscous fluids viscometry
Chhetri, 2014[58] Inline graphic Gold, rod PEG 83 (L), 22 (d) 112 pM* 3D airway & breast culture tissue nanotopology
Oldenburg, 2013[124] Inline graphic Gold, rod PEG 83 (L), 22 (d) <547 pM 3D tumor organoids molecular imaging
PTOCT Chi, 2014[119] Inline graphic Gold, ring NA 155 (OD), 130 (ID), 50 (h) <3.32 pM ex vivo pig liver molecular imaging
Tucker, 2015[54] Inline graphic Gold, rod PEG 45.2 (L),13.2 (d) <200 pM in vivo mouse ear molecular imaging
Xiao, 2013[118] Inline graphic Gold, smart rose C5H7NO3 10 (d)** <60 nM cell culture cancer
Paranjape, 2010[117] Inline graphic Gold, rose dextran ~30 (d) 0.531 pM* phantom macrophages
NA ex vivo aorta
Adler, 2008[51] Inline graphic Gold, shell NA 136 (OD), 120 (ID) <16.6 pM GNP solution molecular imaging
Nahas, 2014[120] Inline graphic Gold, shell PEG 150 (OD), 130 (ID) <4.15 pM ex vivo mouse skin phototherapy
Zhou, 2010[116] Inline graphic Gold, shell NA 152 (OD), 120 (ID) <8.30 pM ex vivo breast tissue molecular imaging
Skala, 2008[52] Inline graphic Gold, sphere PEG 60 (d) 26 pM* liquid phantom molecular imaging
<39 pM cell culture
SOCT Cang, 2005[40] Inline graphic Gold, cage NA 35 (L,w,h) <500 pM phantom molecular imaging
Wei, 2009[97] Inline graphic Gold, rod CTAB NA 2 pM phantom molecular imaging
Oldenburg, 2009[114] Inline graphic Gold, rod CTAB 45 (L), 15 (d) <10-20 nM ex vivo breast tissue breast cancer
Jia, 2015[98] Inline graphic Gold, rod PEG-Tat 50-59 (L), 10 (d) <83 pM cell culture retina
Rawashdeh, 2015[115] Inline graphic Gold, rod CTAB 75 (L), 20 (d) <912 nM ex vivo chicken blood vessels
#

magnetic iron oxide (MIO)

##

indicated by core, outer diameter (OD) inner diameter (ID), length (L), width (w), diameter (d), or height (h)

###

by mass density (w/v); particle density (v−1), particle molarity (pM-nM), or dose (molarity Fe/w)

*

minimum concentration needed for detection

**

particle size within cluster or fluid