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Chemical structures of FXIa inhibitors with tetrahydropyran-3-methylene, glycine, and N-cyclohexylglycine, O-Boc-aspartate, and N-methylpiperazine-4-carbonylmethylene groups as substitutes of phenylalanine. Numbers in brackets represent IC50 values (22–24) Ki values (25–27) toward FXIa.
