. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: Respir Med. 2015 May 23;109(8):1001–1011. doi: 10.1016/j.rmed.2015.05.018

Table 2.

Baseline Pulmonary Function Parameters

		Cystic Fibrosis

	Healthy	All	Heterozygous ΔF508	Homozygous ΔF508
FVC (L)	4.6±0.9	4.0±1.2	3.6±1.4	4.2±1.0
FVC (% predicted)	100±9	96±30	77±21	106±30
FEV₁ (L)	3.8±0.9	2.9±1.1^*	2.7±1.3	3.1±1.0
FEV₁ (% predicted)	99±12	83±28	68±26	91±26
FEV₁/FVC (%)	84±4	73±10 ^*	72±10	74±10
FEF_25–75 (L/s)	4.0±1.2	2.4±1.4 ^*	2.1±1.3	2.5±1.5
FEF_25–75 (% predicted)	96±26	60±30 ^*	51±28	65±32

FVC=forced vital capacity; FEV₁=forced expiratory volume after one second of FVC; FEF_25–75= forced expiratory flow at 25-75% of FVC. Predicted values for all pulmonary function measures were based on predicted equations from NHANES III. Data presented are mean±SD

p<0.025 vs. healthy. Statistics not performed on ΔF508 groups.