Figure 2.

Priority Analysis Screen of SMART Vaccines

A screen showing the various attributes applied by a user for a comparative analysis of 3 hypothetical vaccine candidates—rotavirus, tuberculosis, and pneumococcal pneumonia—for use in South Africa. SMART Scores show the numerical merit values for these vaccine candidates along with a transparent (color‐coded) indication of the contributions from various attributes. The SMART Score for a vaccine candidate for tuberculosis (74) has gained significant contributions from health (premature deaths averted per year and quality‐adjusted life years gained) and economic (cost‐effectiveness) attributes. In this hypothetical assessment, the tuberculosis vaccine outperforms the candidates considered for pneumococcal (42) and rotavirus diseases (25).

Data from the Institute of Medicine, National Academy of Engineering, and the National Academies.