. 2016 Jul 12;11(7):e0158798. doi: 10.1371/journal.pone.0158798

Table 1. Time to achieve apparent volume of distribution to 95% of V_area after the intravenous bolus of the drug and terminal half-life of the drug from E2 and GV models.

V_E (L)	10		15		20		25
	E2	GV	E2	GV	E2	GV	E2	GV
CL = 100 ml/min
time for V_d to reach 95% V_area (min)	50	242	86	646	123	1053	160	1460
terminal half-life of drug	80	81	120	133	160	185	200	238
CL = 40 ml/min
time for V_d to reach 95% V_area (min)	126	604	215	1616	307	2632	399	3650
terminal half-life of drug	200	203	300	333	400	462	500	592

Table 1. Time to achieve apparent volume of distribution to 95% of Varea after the intravenous bolus of the drug and terminal half-life of the drug from E2 and GV models.