Table 4. Top consensus mouse protein regulators identified by MTG-LASSO.
| Category | Gene (Protein name/family) | Module(s) |
|---|---|---|
| Influenza life cycle | Sumo2O (Ubiquitin-like modifier) | 3135, 3147, 3280 |
| Immune response | C3 (Complement protein) | 2810, 2975, 3208,3210 |
| Serpina3k (Serpin peptidase inhibitor) | 3029, 3206 | |
| Serpina3m (Serpin peptidase inhibitor) | 3029, 3159, 3181, 3184, 3186, 3192, 3206, 3207 | |
| S100-A8 | 3141, 3154 | |
| Hemolysis | Hp (Haptoglobin) | 3207, 3210 |
| Hpx (Hemopexin) | 2899, 2976, 3159, 3184, 3192, 3198, 3207 | |
| Mitochondrion | Letmd1 (LETM1-domain containing) | 2950, 3047, 3072, 3135, 3139, 3179, 3187 |
| Splicing | SnrpfK (Spliceosome component) | 3056, 3134, 3135, 3139, 3181, 3193 |
| Other | Fgb (Fibrinogen bet-chain) | 2810, 2977, 3056, 3156 |
| Hopx (HOP homeobox) | 3154, 3280 | |
| 2310036022RikW (C19orf43 homolog) | 3070, 3159, 3199, 3206, 3249 |
Genes are categorized by major biological annotation according to NCBI Entrez, GeneCards, or UniProt. The Module column lists the MTG-LASSO predicted target modules of a protein regulator. Because there were 33 total, we limit presentation here to twelve regulators that were linked to at least two modules. A full list of consensus proteins is available in S8 Table. Genes for which human homologs have been identified as relevant to influenza by a screening or literature study are marked with a superscript: Karlas et al. 2010K; König et al.2010O; Watanabe et al. 2014W.