Table 5. Summary of results of siRNA validation study of seven human protein regulators predicted by MTG-LASSO.

Regulator	Majority viral phenotype
APP	Anti
HIST1H1B	Pro
ISG15	Pro
ITGB4	Anti
PRPF31	Pro
SERPINA3	Anti
THBS1	Pro

Four siRNAs were used per gene. All genes had multiple siRNAs with significant effects, and all had at least one at least ten-fold. However, for most genes, different siRNAs resulted in different effects on virus titer; therefore we characterize each by its majority viral phenotype among the significant siRNAs. Full data and results are available in S7 Table.