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. 2016 Jul 12;11(7):e0158946. doi: 10.1371/journal.pone.0158946

Table 2. The level of miRNA expression in breast cancer tissue and paired sera in different hormonal subtype of breast cancer.

(a) In breast cancer tissue (n = 85)
Hormonal status
miRNA Types TPBC (n = 21) SNBC (n = 20) DNBC (n = 21) TNBC (n = 23)
FC±S.E Regulation P value FC±S.E Regulation P value FC±S.E Regulation P value FC±S.E Regulation P value
miR-21 4.90±0.51 up 0.001* 8.85±2.05 up 0.0001* 14.59±2.09 up 0.0001* 34.641±5.22 up 0.0001*
miR-221 1.33±0.41 up 0.417 2.97±0.53 up 0.001* 19.05±2.56 up 0.001* 28.35±4.04 up 0.001*
miR-210 1.57±0.50 up 0.255 2.99±1.11 up 0.82 18.00±2.86 up 0.0001* 27.82±4.52 up 0.001*
miR-195 0.78±0.08 down 0.007* 0.41±0.07 down 0.001* 0.27±0.06 down 0.001* 0.14±0.04 down 0.001*
miR-145 0.76±0.09 down 0.008* 0.52±0.15 down 0.001* 0.41±0.12 down 0.001* 0.27±0.08 down 0.001*
Let-7a 0.67±0.13 down 0.001* 8.25±1.07 up 0.001* 15.61±1.76 up 0.001* 17.90±2.93 up 0.001*
(b) In breast cancer sera (n = 85)
miRNA Types TPBC (n = 21) SNBC (n = 20) DNBC (n = 21) TNBC (n = 23)
FC±S.E Regulation P value FC±S.E Regulation P value FC±S.E Regulation P value FC±S.E Regulation P value
miR-21 2.42±0.52 up 0.005* 4.17±0.77 up 0.001* 7.84±1.77 up 0.001* 13.99±2.11 up 0.0001*
miR-221 0.45±0.17 down 0.003* 1.81±27 up 0.006* 8.24±1.36 up 0.001* 14.97±2.24 up 0.001*
miR-210 0.88±0.42 down 0.41 1.59±0.74 up 0.868 7.30±1.27 up 0.0001* 8.39±1.34 up 0.0001*
miR-195 0.41±0.05 down 0.001* 0.18±0.06 down 0.001* 0.10±0.03 down 0.001* 0.05±0.01 down 0.001*
miR-145 0.37±0.07 down 0.001* 0.18±0.06 down 0.001* 0.14±0.04 down 0.001* 0.08±0.03 down 0.001*
Let-7a 0.47±0.08 down 0.001* 5.22±0.77 up 0.001* 9.80±1.38 up 0.001* 11.84±1.99 up 0.001*

Abbreviations: TPBC: Triple Positive Breast Cancer; SNBC: Single Negative Breast Cancer; DNBC: Double Negative Breast Cancer; TNBC: Triple Negative Breast Cancer; FC: Fold change; S.E: Standard Error mean;

* Significant.