Table 4. Receiver operating characteristic curve (ROC) analysis for the set of 5 microRNAs for differentiating TNBC in tissues and sera.
(a) ROC for TNBC tissues (n = 23) | ||||
miRNA | Sensitivity | Specificity | AUC (95% CI) | P value |
miR-21 | 100% | 95% | 0.9977 (0.9903–1.000) | p < 0.0001* |
miR-221 | 100% | 100% | 1.000 (1.000–1.000) | p < 0.0001* |
miR-210 | 95% | 95% | 0.9783 (0.9347–1.022) | p < 0.0001* |
miR-195 | 73% | 78% | 0.7580 (0.6058–0.9103) | p = 0.0027* |
miR-145 | 73% | 60% | 0.7013 (0.5489–0.8538) | p = 0.0193* |
Let-7a | 95% | 95% | 0.9773 (0.9411–1.014) | p < 0.0001* |
(b) ROC for TNBC sera (n = 23) | ||||
miR-21 | 95% | 81% | 0.9587 (0.9071–1.000) | p < 0.0001* |
miR-221 | 81% | 72% | 0.8099 (0.6629–0.9570) | p = 0.0004* |
miR-210 | 100% | 100% | 0.9979 (0.9911–1.000) | p < 0.0001* |
miR-195 | 78% | 65% | 0.6767 (0.5098–0.8437) | p = 0.0400* |
miR-145 | 78% | 91% | 0.8837 (0.7862–0.9812) | p < 0.0001* |
Let-7a | 91% | 86% | 0.9660 (0.9237–1.008) | p < 0.0001* |
AUC: Area Under the Curve; CI: Confidence Interval;
* Significant.