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. 2016 Jul 12;12(7):e1004763. doi: 10.1371/journal.pcbi.1004763

Fig 3. Example of a four-state 1 parameter Markov chain model.

Fig 3

Note that in this diagram, transitions between states A and D have been disallowed; it is conventional to not draw the arrow rather than to draw it with a rate of 0.