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. 2016 Jun;54(6):892–900. doi: 10.1165/rcmb.2015-0068OC

Figure 4.

Figure 4.

Decreased expression of NgBR results in increased proliferation, migration, and ROS formation of PASMCs. (A) NgBR KD decreases its protein level in NFL, and OE increases NgBR protein in HTFL PASMCs (n = 3). (B) Cell counts were higher after NgBR KD in NFL PASMCs compared with NS siRNA–treated cells at all time points. NgBR OE decreases cell counts at all time points in HTFL PASMCs (n = 8). (C) NgBR OE in HTFL PASMCs leads to decreased migration when compared with controls, both at basal levels and in response to stimulation with PDGF. NgBR KD in NFL PASMCs leads to increased basal and PDGF-stimulated migration when compared with control (n = 10). (D) NgBR KD in NFL PASMCs increases DHE fluorescence intensity, whereas NgBR OE in HTFL PASMCs decreases DHE fluorescence intensity (n = 10). *P < 0.05 between two groups. Data are shown as mean (±SE).