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. Author manuscript; available in PMC: 2016 Jul 12.
Published in final edited form as: Chin Clin Oncol. 2015 Mar;4(1):11. doi: 10.3978/j.issn.2304-3865.2015.02.01

Figure 2.

Figure 2

Oncogenic survival signaling components in PCNSL. Activation of the TLR/MYD88 pathway may directly contribute to pro-survival signaling directly via NFkB as well as via the enhanced production of IL-10 which itself contributes to survival signals via the JAK/STAT pathway. GPCR, G protein-coupled receptor.