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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):474–484. doi: 10.1097/QAI.0000000000001000

Figure 2. HIV infected children have selective expansion of memory FOXP3+Helios+ Tregs that correlates with advancing HIV disease status.

Figure 2

(A) Frequencies of FOXP3+Helios+ and FOXP3+Helios- in CD45RO+ (memory) CD4 T cells and FOXP3+Helios+ in CD45RO- (naïve) CD4 T cells in HIV-, ART-, and ART+ children. Graphs show medians with interquartile ranges. P-value reported for two-sided Mann-Whitney test with threshold significance of 0.05. (B) Percent of FOXP3+Helios+ in memory CD4 T cells vs. CD4 percent in total lymphocytes (top) and CD4:CD8 ratio (middle) in HIV-, ART-, and ART+ children. (B, bottom) Percent of FOXP3+Helios+ in memory CD4 T cells vs. plasma HIV RNA log copies/ml in ART- and ART+ children with HIV viral load above the detection limit 110 copies/ml. HIV- shown in open circles (○); HIV+ in filled circles (●). P- and r- values were calculated with Spearman's correlation test.