Table 1.
Chronology of the TB control program in Karakalpakstan, Uzbekistan
| Date | Activity |
|---|---|
| July 1998 | First patient entered in DOTS program in Muynak district |
| June 2001 | Launch of DST study |
| July 2002 | First staff appointed to MDR-TB program (MDR-TB medical doctor position) |
| April 2003 | Ministry of Health of the Republic of Uzbekistan issued Decree No. 160 on management of TB [21] |
| August 2003 | DOTS expanded to the last uncovered district Turtkul |
| September 2003 | Start of DOTS-Plus program. First MDR-TB patients admitted to Republican TB Hospital No. 2 in Nukus |
| October 2004 | Outpatient department opens in Nukus city for ambulatory care of MDR-TB patients discharged from MDR-TB hospital |
| May 2005 | First MDR-TB patient cured |
| September 2005 | Signed memorandum of understanding with Foundation for Innovative New Diagnostics for rapid DST |
| January 2006 | GFATM TB program starts to supply second-line TB drugs for Karakalpakstan |
| October 2007 | Ministry of Health of the Republic of Karakalpakstan issued Decree No. 366 on expansion of ambulatory care of drug-resistant TB through early discharge into ambulatory care |
| May 2008 | Ministry of Health of the Republic of Uzbekistan issued Decree No. 180 on management of MDR-TB |
| August 2010 | “Comprehensive TB Care for All” program approved in Karakalpakstan |
| February 2011 | Ministry of Health of the Republic of Karakalpakstan issued Decree No. 39 on “Comprehensive TB Care for All” program expansion and management of TB [23] |
| March 2011 | Cabinet of Ministers of the Republic of Uzbekistan issued Decree No. 62 on construction, reconstruction and refurbishment of TB facilities, and optimization of inpatient facilities through abolition of low capacity inefficient TB facilities [35] |
| December 2015 | “Comprehensive TB Care for All” program implemented in all districts |
DOTS directly observed treatment, short-course; DOTS-Plus is a management strategy for MDR-TB built upon the elements of DOTS, DST drug susceptibility testing, GFATM Global Fund to Fight AIDS, Tuberculosis and Malaria, MDR-TB multidrug-resistant tuberculosis, MSF Médecins Sans Frontières. Source: WHO [56] and own compilation