Table 1. Genes significantly expressed in beta cells but with differential expression in ST8SIA1+/− subtypes.
| Gene | FC (ST8SIA1+/ST8SIA1−) | P | FDR | |
|---|---|---|---|---|
| ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 12.52 | 7.1E-11 | 0 |
| HCN1 | Hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 | 3.03 | 1.5E-04 | 0.03 |
| DAB1 | Dab, reelin signal transducer, homologue 1 (Drosophila) | 2.21 | 2.9E-05 | 0.01 |
| KCND3 | Potassium channel, voltage-gated Shal-related subfamily D, member 3 | 2.16 | 7.8E-09 | 0 |
| SIX3 | SIX homeobox 3 | 2.01 | 1.9E-09 | 0 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 1.98 | 4.2E-04 | 0.05 |
| KCNJ8 | Potassium channel, inwardly rectifying subfamily J, member 8 | 1.9 | 6.8E-04 | 0.07 |
| SPP1 | Secreted phosphoprotein 1 | 1.87 | 4.7E-09 | 0 |
| TFF3 | Trefoil factor 3 (intestinal) | 1.81 | 8.3E-13 | 0 |
| ITGA1 | Integrin, alpha 1 | 1.76 | 2.3E-04 | 0.04 |
| KCNE4 | Potassium channel, voltage-gated subfamily E regulatory beta subunit 4 | 1.76 | 6.4E-04 | 0.06 |
| RBM43 | RNA-binding motif protein 43 | 1.57 | 3.5E-04 | 0.04 |
| SCN3A | Sodium channel, voltage-gated, type III, alpha subunit | 1.57 | 7.3E-04 | 0.07 |
| ABCC9/SUR2* | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 1.54 | 3.2E-05 | 0.01 |
| SULF2 | Sulfatase 2 | 1.49 | 2.2E-05 | 0.01 |
| PON3 | Paraoxonase 3 | 1.43 | 5.3E-04 | 0.06 |
| GSN | Gelsolin | 1.4 | 7.3E-06 | 0 |
| OXCT1 | 3-oxoacid CoA transferase 1 | −1.33 | 2.8E-05 | 0.01 |
| TMCC3 | Transmembrane and coiled-coil domain family 3 | −1.33 | 8.2E-05 | 0.02 |
| NEUROD1* | Neuronal differentiation 1 | −1.34 | 1.0E-03 | 0.09 |
| FAM159B | Family with sequence similarity 159, member B | −1.36 | 6.7E-05 | 0.02 |
| MAFB* | v-maf avian musculoaponeurotic fibrosarcoma oncogene homologue B | −1.38 | 1.4E-04 | 0.03 |
| SPTLC2 | Serine palmitoyltransferase, long-chain base subunit 2 | −1.38 | 2.2E-04 | 0.03 |
| TNFRSF21 | Tumour necrosis factor receptor superfamily, member 21 | −1.39 | 4.5E-07 | 0 |
| G6PC2 | Glucose-6-phosphatase 2 | −1.46 | 3.2E-09 | 0 |
| RFX6* | regulatory factor X, 6 | −1.46 | 9.0E-07 | 0 |
| SCGB2A1 | Secretoglobin, family 2A, member 1 | −1.49 | 8.9E-09 | 0 |
| SLC2A2/GLUT2* | Solute carrier family 2 (facilitated glucose transporter), member 2 | −1.53 | 7.2E-05 | 0.02 |
| HCN4 | Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 | −1.77 | 9.4E-04 | 0.08 |
FC, fold change; FDR, false discovery rate.