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. 2016 Jul 11;6:29703. doi: 10.1038/srep29703

Figure 7. Inhibition of intracellular pathways, gene expression of BMP target gene ID1 and tendon marker scleraxis.

Figure 7

Box plot graphs represent qRT-PCR values given as mean normalised expression relative to 18S rRNA and the untreated control (reference line) using an efficiency corrected formula (n = 3). Inhibitors for the specific pathway were used in two concentrations. The inhibition of the Smad-pathway by LDN-193189 (LDN) resulted in a significant reduction of ID1 and scleraxis expression, less reduction was seen after inhibition of the p38 pathway with PD169316 (PD) and no effect after inhibition of the Akt-pathway (Akt), *p < 0.003, #p < 0.04, compared to BMP-7.