Table 1. Adoptive transfer of CpG-proB cells but not of control pro-B cells inhibits ongoing EAE.
Group | Mice | Mean maximum score±s.e.m. | Day of onset±s.e.m. | Disease incidence |
---|---|---|---|---|
Control | 30 | 3.51±0.89 | 13.56±1.40 | 100% |
WT CpG-proBs | 30 | 1.56±1.26** | 14.50±2.22 | 76.7%* |
Control ProBs | 20 | 3.57±0.92 | 13.30±2.22 | 100% |
PBS-proBs | 4 | 3.50±0.05 | 12.00±0.00 | 100% |
Clinical parameters from data in Fig. 1e, including the maximum clinical score (mean±s.e.m.) of each treatment group and the day of disease onset (mean±s.e.m.) among mice with EAE as well as the disease incidence over the entire observation period (35 days). Control mice received PBS injection instead of progenitor injection. Significant differences between CpG-proB recipients versus control mice are indicated; *P<0.05, **P<0.005, assessed by non-parametric Mann–Whitney's t-test.