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. 2016 Jul 11;7:12161. doi: 10.1038/ncomms12161

Figure 6. A model of sequential and hierarchical recruitment of effectors to LAT clusters.

Figure 6

A model that summarizes the set of hierarchical molecular interactions (left) that lead to the hierarchical structure (right) of LAT-nucleated clusters and intact T-cell activation. PLCγ1 and VAV1 show mutual interaction synergy, interpreted here as cooperativity, in their recruitment to LAT clusters. SLP-76 molecules in proximity to PLCγ1 or actin showed enhanced proximity to LAT molecules, but proximity to SLP-76 did not increase the recruitment of PLCγ1 or VAV to LAT. The clusters are ordered such that VAV1 molecules are closest to LAT in the centre of the cluster, PLCγ1 molecules are the next closest, with most SLP-76 and actin molecules around the periphery.