Skip to main content
. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: Annu Rev Psychol. 2012;63:129–151. doi: 10.1146/annurev.psych.121208.131631

Figure 5.

Figure 5

Prefrontal-amygdala interaction in rodents and humans. A. The tone response of a single PL neuron (blue line, z-score) superimposed upon the rat's freezing to the tone (gray bars). Adapted from Burgos-Robles et al., 2009. Note the high correlation between sustained PL activity and freezing (bin: 3 sec). B. Left: Schematic illustrating reciprocal connections between PL and the BLA. Transient tone response emanating from BLA trigger sustained tone responses in PL that feedback to BLA and drive fear. Right: perievent time histogram showing a conditioned tone response of a PL neuron under control conditions (black bars), and after inactivation of BLA with infusion of muscimol (red bars). Fear signals in BLA drive PL. C. Psychophysiological interaction (PPI) analysis during extinction recall in healthy humans. During recall of a non-extinguished stimulus, increased coupling of the neural activity of the amgydala (seed) with the dACC (red circle) was observed, and reduced functional coupling between the amgydala (seed) and vmPFC (green circle) was observed (adapted from Linnman et al. (2011c).