Figure 2. Morris water maze assessment of Pdx1^+/−/APP/PS1 mice.

(A) The results of the hidden platform tests did not differ between the Pdx1^+/− and WT control groups. The APP/PS1 mice exhibited a significantly longer escape latency than that of the control mice, and the Pdx1^+/−/APP/PS1 mice exhibited a significantly poorer performance than that of the APP/PS1 mice at 40 weeks of age. (B) Memory test in the MWM probe trial without the platform. During the probe trial, the APP/PS1 and Pdx1^+/−/APP/PS1 mice traveled to the center of the quadrant fewer times than did the WT mice. Note that the deficits in the Pdx1^+/−/APP/PS1 mice were increased compared with those of the APP/PS1 mice. Data represent the mean ± S.E. (n = 10). *p < 0.05, **p < 0.01 compared with the WT control group; ^#p < 0.05, ^##p < 0.01 compared with the APP/PS1 group.