Figure 4. Analysis of the modulation of Aβ signaling mechanisms.

(A) Western blots showing the protein levels of APP695, p-APP668, ADAM-10, BACE-1, sAPPα, sAPPβ, CTFs, PS1, and IDE in the homogenized brain tissues of Pdx1^+/−, APP/PS1, Pdx1^+/−/APP/PS1, and WT littermate mice at 41 weeks of age. GAPDH was used as an internal control. (B–J) Quantitative analyses of the immunoreactivities to the antibodies presented in the previous panel. Data represent the mean ± S.E. (n = 10). *p < 0.05, **p < 0.01 compared with the WT control group; ^#p < 0.05, ^##p < 0.01 compared with the APP/PS1 group.