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. 2016 Jul 12;6:29396. doi: 10.1038/srep29396

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Western blots showing the protein levels of GSK3α/β, p-GSK3α/β, ERK1/2, p-ERK1/2, JNK1/2, p-JNK1/2, P38, p-P38, Cdk5, p35, p25 and PP2A in the homogenized brain tissues of Pdx1^+/−, APP/PS1, Pdx1^+/−/APP/PS1, and WT littermate mice at 41 weeks of age. GAPDH was used as an internal control. (B–K) Quantitative analyses of the immunoreactivities to the antibodies presented in the previous panel. Data represent the mean ± S.E. (n = 10). *p < 0.05, **p < 0.01 compared with the WT control group; ^#p < 0.05, ^##p < 0.01 compared with the APP/PS1 group.

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