Figure 7. Upregulated AGE/RAGE signaling in Pdx1^+/−/APP/PS1 mouse brains.

(A) Western blots demonstrating the protein levels of GLUT1, GLUT3, AGE, RAGE, and NF-κB in the brains of Pdx1^+/−, APP/PS1, Pdx1^+/−/APP/PS1, and WT littermate mice at 41 weeks of age. GAPDH was used as an internal control. (B–F) Quantitative analyses of the immunoreactivities to the antibodies presented in the previous panel. (G) ROS content was increased markedly in the hippocampus of Pdx1^+/−/APP/PS1 mice compared with APP/PS1 mice. Data represent the mean ± S.E. (n = 10). *p < 0.05, **p < 0.01 compared with the WT control group; ^#p < 0.05, ^##p < 0.01 compared with the APP/PS1 group.