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Ratio of ceftolozane concentrations between bone tissue and plasma.
| Dose | Time after last dose (hours) | Bone : serum concentration ratio | |
|---|---|---|---|
| Rabbit model | 1 g q 8 h | 1.5 |
Marrow: 14.1%–17.5% Bone: 6.2%–9.0% |
| Rat model | 20 mg/kg | 2 | 27% |
| 8 | 40% |
Source: unpublished manufacturer data.
