Table 1.
Effect of siRNAs used individually and in combination on HCV replication. Only combination of La autoantigen with hVAP-A or HCV NS5B shows syndergistic effect on HCV inhibition. Other combinations of siRNAs could not improve the overall level of inhibition of HCV.
| Target gene (siRNA position) | Target gene silencing (%) | Reduction of HCV after single gene silencing (%) | Reduction of HCV after multiple gene silencing (%) | |||
|---|---|---|---|---|---|---|
| (+) La autoantigen | (+) hVAP-A | (+) PSMA7 | (+) NS5B | |||
| La autoantigen (1064–1081) | 96.5 | 67.2 | — | — | — | — |
| hVAP-A (5929–5953) | 50.1 | 39.0 | 82.2↑ | — | — | — |
| PSMA7 (199–217) |
65.0 | 50.7 | 69.9↑ | 49.0↓ | — | — |
| HCV NS5B (531–549) |
52.0 | 52.0 | 85.6↑ | 53.3↓ | 43.8↓ | — |