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. 2016 Jul 11;6:29378. doi: 10.1038/srep29378

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Copyright © 2016, Macmillan Publishers Limited

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Concentration-activation relationships for heterotetrameric CNG channels containing different disabled subunits and cGMP. The voltage was +100 mV. The data points represent means of 7–12 measurements each. The continuous curves (red) are the best fit with equation (2). The fits suggest the presence of a component with high apparent affinity (dashed gray lines) and a component with low apparent affinity. (a) CNGA2_RE:A4_RE:B1b. EC_50,l = 177.8 μM cGMP, H_l = 1.2, EC_50,h = 3.6 μM cGMP, H_h = 1.0 (fixed), a = 0.07. (b) CNGA2_RE:A4:B1b_RE. EC_50,l = 364.2 μM cGMP, H_l = 1.1, EC_50,h = 8.86 μM cGMP, H_h = 1.0 (fixed), a = 0.24. (c) CNGA2_RE:A4:B1b. EC_50,l = 733.2 μM cGMP, H_l = 1.2, EC_50,h = 5.7 μM cGMP, H_h = 1.05, a = 0.89. The fit parameters are summarized in Table 1.