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. 2016 Jul 11;6:29378. doi: 10.1038/srep29378

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Copyright © 2016, Macmillan Publishers Limited

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Superimposition of activation (a) and deactivation (b) time courses following a concentration jump to 10 μM fcGMP and back to zero for CNGA2 (green), CNGA2:A4:B1b (black), CNGA2_RE:A4_RE:B1b (blue), and CNGA2_RE:A4:B1b_RE (orange) channels. The traces are averages obtained from 5–7 traces obtained from different patches. All traces were normalized with respect to the initial and late current (I/I_max). The voltage was set to +10 mV. The respective activation and deactivation time courses of the individual measurements were fitted with monoexponential functions apart from the activation of CNGA2_RE:A4_RE:B1b channels that required a biexponential function (Equation S1, Supplementary Information). The time constants are illustrated by bar graphs below the traces. For small differences a t-test with respect to CNGA2:A4:B1b channels was performed. An asterisk indicates a significant difference (p < 0.05).