Table 2. Ligand binding to the modulatory subunits.
Constructs | CNGA4 | CNGB1b | ||
---|---|---|---|---|
fcGMP | fcGMP | fcAMP | fHcAMP | |
10 μM | 10 μM | 10 μM | 2 μM | |
CNGA4* | − | |||
CNGB1b* | − | |||
CNGA2RE:A4* | + | |||
CNGA2TM:A4 | + | |||
CNGA2TM:A4RE* | − | |||
CNGA2RE:B1b | − | − | − | |
CNGA2TM:B1b | − | |||
CNGA2RE:A4RE:B1b | − | + | + | |
CNGA2RE:A4RE:B1bRE | − | − | − | |
CNGA2TM:A4RE:B1b | − | + | ||
CNGA2TM:A4RE:B1bRE | − | − |
*from Nache et al., 2012.
The symbols “+” and “−” indicate that ligand binding to the respective modulatory subunits was either observed or not.